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Transplantation of mesenchymal stem cells from young donors delays aging in mice

Increasing evidence suggests that the loss of functional stem cells may be important in the aging process. Our experiments were originally aimed at testing the idea that, in the specific case of age-related osteoporosis, declining function of osteogenic precursor cells might be at least partially responsible. To test this, aging female mice were transplanted with mesenchymal stem cells from aged or young male donors. We find that transplantation of young mesenchymal stem cells significantly slows the loss of bone density and, surprisingly, prolongs the life span of old mice. These observations lend further support to the idea that age-related diminution of stem cell number or function may play a critical role in age-related loss of bone density in aging animals and may be one determinant of overall longevity.

Sci Rep. 2011;1:67. http://www.ncbi.nlm.nih.gov/pubmed/22355586

MORE RESEARCH

STEM CELL TRANSPLANTATION IMPROVES AGING-RELATED DISEASES

Aging is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable ...

READ


LONG-TERM CRYOPRESERVATION OF BONE MARROW FOR AUTOLOGOUS TRANSPLANTATION

Little is known about the effect of long-term cryopreservation on the viability of hematopoietic stem cells (HSC) ...

READ  

Transplantation of mesenchymal stem cells from young donors delays aging in mice

Increasing evidence suggests that the loss of functional stem cells may be important in the aging process. Our experiments were originally aimed at testing the idea that, in the specific case of age-related osteoporosis, declining function of osteogenic precursor cells might be at least partially responsible. To test this, aging female mice were transplanted with mesenchymal stem cells from aged or young male donors. We find that transplantation of young mesenchymal stem cells significantly slows the loss of bone density and, surprisingly, prolongs the life span of old mice. These observations lend further support to the idea that age-related diminution of stem cell number or function may play a critical role in age-related loss of bone density in aging animals and may be one determinant of overall longevity.

Sci Rep. 2011;1:67. http://www.ncbi.nlm.nih.gov/pubmed/22355586

MORE RESEARCH

STEM CELL TRANSPLANTATION IMPROVES AGING-RELATED DISEASES

Aging is a complex process of damage accumulation, and has been viewed as experimentally and medically intractable ...

READ


LONG-TERM CRYOPRESERVATION OF BONE MARROW FOR AUTOLOGOUS TRANSPLANTATION

Little is known about the effect of long-term cryopreservation on the viability of hematopoietic stem cells (HSC) ...

READ